Dysregulation of Amino Acid Transporters in a Rat Model of TLR7-Mediated Maternal Immune Activation
نویسندگان
چکیده
Maternal immune activation (MIA) during pregnancy is linked to neurodevelopmental disorders in humans. Similarly, the TLR7 agonist imiquimod alters neurodevelopment rodents. While mechanisms underlying MIA-mediated changes are unknown, they could involve dysregulation of amino acid transporters essential for neurodevelopment. Therefore, we sought determine nature such transporter both imiquimod-treated rats and human placentas infection. Pregnant received on gestational day (GD)14. Transporter expression was measured fetal brains via qPCR (GD14.5) immunoblotting (GD16). To monitor function, brain levels were by HPLC GD16. Gene cortex female further examined RNAseq GD19. In placentas, suspected active infection associated with decreased ASCT1 SNAT2 protein expression. rats, also male while EAAT2 placentas. CAT3 increased brains. Consistent this, altered brains, demonstrated several genes implicated autism. Thus, pregnant similar occur This suggests that may contribute effects mediated MIA toward
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ژورنال
عنوان ژورنال: Pharmaceutics
سال: 2023
ISSN: ['1999-4923']
DOI: https://doi.org/10.3390/pharmaceutics15071857